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We believe that our data support similar patterns of coexistence for both sexes, but given the rarity of autoimmune diseases in males, the associations among males are more challenging to detect. Regarding other conflicting evidence, there are also data demonstrating that autoimmune therapies may not always lead to increased risk for further disorders. Chouhfeh and colleagues investigated how disease modifying therapies impact comorbid autoimmune diseases in MS using data from a cohort of 1, patients in the New York State MS Consortium registry.

There were 1, patients with no other autoimmune diseases and with a comorbid condition that occurred after enrollment.

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Disease-modifying therapies failed to alter the frequency of self-reported autoimmune disorders Sreih highlighted this paper also shows that women are at higher risk of developing autoimmune diseases than men. He also had some comments about the limitations of the paper. However, some medications may cause autoimmune diseases more than others and therefore one cannot generalize to all medications. It would have been interesting to know which medications were more associated with autoimmune disorders or with shorter duration to developing an autoimmune disorder than others.

A number of comorbid autoimmune conditions have been described extensively. The aim was to assess prevalence rates of coexisting autoimmune disorders. A second autoimmune disorder occurred in 9. RA was the most frequently reported comorbid condition, occurring in 3. The parents of index cases also experienced increased relative risks for a number of other coexisting autoimmune disorders.

Gill and colleagues investigated prevalence of comorbid autoimmune diseases in a cohort of 1, patients with vitiligo at Henry Ford Health System in Detroit during January and October The researchers reported increased rates of a number of conditions in vitiligo patients compared with the general population, including thyroid disease Sreih said vitiligo can accompany many autoimmune diseases and may be associated with many autoimmune polyendocrinopathies. The studied population in this paper belongs to one hospital and one specific geographic area of Detroit.

Rheumatic Rarities, An Issue of Rheumatic Disease Clinics, E-book

Another key point was thyroid disease was the most common comorbid disease in this population, according to Sreih. Lauret and Rodrigo addressed approaches to dealing with celiac disease, which remains poorly understood. A gluten-free diet has demonstrated the capacity to improve clinical symptoms of celiac disease, including associated conditions, according to Lauret and Rodrigo.

This diet may eliminate anemia or offer improved control of type 1 diabetes. The presence of other autoimmune conditions gives us a lot of information about these patients. We should be paying attention to this. The good news is drug developers are investigating drugs that minimize the risk of a second condition in patients with MS and other primary disorders, according to Berkovich.

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Login Register My Saved. Cover Story. Healio Rheumatology, August Please provide your email address to receive an email when new articles are posted on this topic. Receive an email when new articles are posted on this topic. You have already added this topic to your email alerts. Click here to manage your alerts. Regina Berkovich Healio Rheumatology lays out the issues and associations, beginning with a look at trends in comorbid autoimmune diseases. Overview of Associations Cojocaru and colleagues outlined factors involved in multiple autoimmune syndrome, which they defined as the existence of three or more of these conditions.

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Conflicting Data Although the overwhelming consensus is that autoimmune diseases co-occur, there are data sets that show the opposite or at least muddy the picture. Emily C. Commonly Reported Associations A number of comorbid autoimmune conditions have been described extensively. US Neurology. Boelaert K, et al. Am J Med. Chouhfeh L, et al.

Multiple Sclerosis and Related Disorders. Cojocaru M, et al. Maedica Buchar. Farez MF, et al.

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Multiple Sclerosis International. Gill L, et al. J Am Acad Dermatol. Lauret E, et al.

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BioMed Research International. Ni C, et al. Clin Cosmet Investig Dermatol. S Sardu C, et al. Hence, a practical guide to the diagnosis and treatment of lupus would be valuable to an array of clinicians and may help expedite earlier diagnosis and better patient care. The target audience is rheumatologists in training and primary care physicians who care for lupus patients and allied health professionals who assist in their management. The book will fulfill a need for a concise, practical guide to Lupus for clinicians that distills the principal features of this complicated, often misunderstood disorder.

Daniel J. Wallace is one of the world's leading authorities on the disorder, an eminent clinician who has treated over 2, lupus patients, the largest such practice in America. He is the author of another Oxford book--The Lupus Book, and the editor of the premier authoritative lupus textbook, Dubois' Lupus Erythematosus. Ellen M. This issue brings the rheumatologist on the current thinking on treatment of Systemic Lupus Erythematosus, with an eye to the future.

Topics covered include B cell biology and related therapies; glutamate receptor biology and its clinical significance in neuropsychiatric SLE; platelet C4d and vascular complications; biomarkers in lupus nephritis; endothelial function and its implications for cardiovascular and renal disease in SLE; changing worldwide epidemiology of SLE and its relationship to environmental, ethnic, and other sociodemographic factors; work loss, disability, quality of life, and compliance in SLE; pediatric lupus; metabolic syndrome and related endocrine abnormalities; the significance of interferon and the consequences of anti-interferon in SLE; and cutaneous lupus and the CLASI instrument.

George Tsokos. This new companion to Hochberg et al. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage.


Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Jonathan Kay. Guest edited by Jonathan Kay, this issue of Rheumatic Disease Clinics will cover the latest research and evidence surrounding the diagnosis, treatment and management of rarely seen rheumatic diseases. Marcy B. Corticosteroids represent the most important and frequently used class of anti-inflammatory and immunosuppressant agents in the management of many rheumatological conditions. Included in this issue will be articles on the following topics: Glucocorticoid use in intra-articular and soft tissue injections, corticosteroids and osteoporosis, corticosteroids in lupus, ANCA associated vasculitis, and many more!

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Rheumatic Rarities, An Issue of Rheumatic Disease Clinics, E-book

This copy is now passed to you. The New Sjogren's Syndrome Handbook. Sjogren's Syndrome Foundation,. Afflicting nearly four million Americans, Sjogren's syndrome is an autoimmune disease that commonly causes dryness of the eyes, mouth, and nose, and that can lead to complications including profound fatigue, depression, and lymphoma. While there is no cure for Sjogren's, much can be done to alleviate the suffering of patients. This extensively revised handbook offers everything you need to know to cope with this disease.

Wallace, a leading authority on auto-immune disorders. This expanded edition provides readers with the best medical and practical information on this disorder, bringing together the current thinking about Sjogren's in an easily readable and understandable book. The handbook illuminates the major clinical aspects of the syndrome and is loaded with practical tips and advice to assist those seeking information.

Indeed, it offers a wide-ranging look at the many faces of Sjogren's, covering diagnosis, the various organ systems that can be affected, the possible psychological problems, and the many treatment options, as well as an appendix listing the resources available for patients with the disease. It is a valuable aid that patients can use while discussing their illness with their physician and an excellent resource for family members.

And because Sjogren's is greatly underdiagnosed, this handbook is a particularly valuable resource for healthcare professionals. The most reliable and informative guide available, The New Sjogren's Syndrome Handbook, Third Edition is the first place for patients to look when they have questions about this little known but serious chronic disease. The varieties and classes of droids are nearly as infinite as their designated specialties. In this updated and expanded nuts-to-bolts survey, each and every droid receives its due—from the simplest drones to the most sophisticated automatons, from heroic protocol model, C-3PO, and his multitasking sidekick, R2-D2, to the insidious Separatist leader General Grievous.

The Sjogren's Book: Edition 4.